Cancer Genomics

Hormone-Dependent Cancers

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Hormones influence not only breast and prostate cancer, the two most common hormone-dependent cancers, but also have a major impact on less common hormone-sensitive malignancies (e.g. ovary, testes, endometrium) as well as human cancers recently discovered to be hormone sensitive (e.g. lung, liver). Developing a means to more specifically treat and ideally prevent hormone-dependent cancers is of critical importance given the significant impact these malignancies have on human health and the economic burden of disease. An in depth understanding of hormone action in regulating diverse cellular processes, cancer phenotypes and drug responsiveness is essential for the development of effective and well tolerated treatment strategies.