5th International Conference on Cancer Genomics
Las Vegas, USA
Adel Gouri
Badji-Mokhtar University, Algeria
Title: CDA-NABC-cytidine deaminase activity a predictive marker of toxicity/efficacy in nucleosidic analogs-based chemotherapy
Biography
Biography: Adel Gouri
Abstract
Nucleoside analogues such as gemcitabine and cytarabine are widely prescribed in pediatric and adult oncology. However, large variability in clinical outcome and efficacy has been observed. Therefore, new biomarkers with predictive power to assess inter-individuals differences in clinical outcome are urgently warranted. Cytidine Deaminase (CDA) is a liver enzyme that plays a crucial role in the metabolism of nucleoside analogues, coded by a gene displaying several genetic and epigenetic polymorphisms. Consequently, CDA activity is present various phenotypes, ranging from deficient (Poor Metabolizer patients, PM), to ultra-rapid deaminator patients (Ultra-Metabolizer patients, UM), with subsequent impact on drug pharmacokinetics and pharmacodynamics eventually. Several studies showed that CDA status was well correlated with clinical outcomes in patients undergoing nucleosidic analogs-based chemotherapy. Therefore, a low CDA activity is associated with more toxicity but a higher efficacy, while a high activity will lead to a lower efficacy but less toxicity. CDA phenotypic screening and prior stratification of patients’ status should be considered as relevant strategy to personalize dosing and to improve efficacy/toxicity ratio.