Whole Genome Sequencing

The advance of whole genome sequencing technology accelerates the identification of key genetic trait or alteration leading to disease development. The major function of current massively parallel genome sequencers is to perform de novo assembly or resequencing of euchromatic regions, about 94% of entire human genome and representing the reference genome firstly obtained after completion of Human Genome Project.  Massively parallel short or medium reads of tens to few thousands with sufficient coverage are able to piece together contiguous euchromatic sequences tolerating 1-4% error rate primarily from inherited DNA polymerase infidelity. However, these short- or medium-read sequencers are not suitable for determining heterochromatic sequences, which cover the yet-to-be completed 6% human genome and contain long repetitive nuclear elements, including the 45S rDNA , about 45-kb per copy and estimated 400 copies distributed across short arms of five human acrocentric chromosomes, and satellite DNAs in centromere. The tandemly repeated 45S rDNA and satellite DNAs are recombinational hot spots and are sealed throughout eukaryotes. Recent evidence further suggests that 45S rDNA rearrangement and concurrent epigenetic changes play a role in mammalian ontogeny and tissue differentiation, and are associated with speciation, aging, cancers, psychological disorders, and neurodegenerative diseases. 

The need to develop sequencing platforms capable of reading continuously a single long-stretch DNA/RNA strand with high accuracy is urgent. Several newly proposed approaches show a potential to achieve long-reads of 50 kb or more, and are at various stages of development toward commercialization. These include new version of single molecule real time (SMRT) technology, biological and solid-state nanopore, nanogap, nanoribbon, nanochannel, and electron microscopy, which are moving away from fluorescence-based detection to electronic sensing or imaging. 

  • Whole genome sequencing
  • Next Generation Sequencing
  • Third generation sequencing
  • De novo sequencing
  • Targeted gene sequencing
  • Trends in DNA and RNA sequencing techniques

Related Conference of Whole Genome Sequencing

September 25-27, 2017

17th Euro Biotechnology Congress

Berlin, Germany
September 27-28, 2017

Annual Summit on Cell Therapy and Molecular Medicine


(10 Plenary Forums - 1Event)
Chicago, Illinois, USA
September 27-28, 2017

Annual Summit on Cell Signaling and Cancer Therapy


(10 Plenary Forums - 1Event)
Chicago, Illinois, USA
October 19-20, 2017, Hilton New York JFK Airport Hotel

18th Biotechnology Congress

New York, USA
October 20-21, 2017

3rd World Congress on Human Genetics & Genetic Disorders

Toronto, Canada
October 23-24, 2017

10th World Congress on Stem Cell and Biobanking

Osaka, Japan
November 13-14, 2017

19th World Congress on Biotechnology

Osaka, Japan
December 04-05, 2017

2nd World Biotechnology Congress


(10 Plenary Forums - 1Event)
Sao Paulo, Brazil
December 11-12, 2017

3rd World Bio Summit & Expo

Dubai, UAE
March 5-7, 2018

20th Global Congress on Biotechnology

London, UK
May 14-15, 2018

11th World Congress on Cell & Tissue Science

Tokyo, Japan
May 21-23, 2018

6th International Conference on Integrative Biology

Barcelona, Spain
July 2-3, 2018

4th International Conference on Bioscience

Vienna, Austria
July 9-10, 2018

8th World Congress on Plant Science & Genomics

Sydney, Australia
September 24-25, 2018

3rd World Congress on HUMAN GENETICS

Berlin, Germany
Heidelberg Germany

1st EMBL Conference Cancer Genomics Heidelberg Germany

1st to 4th November 2015
San Francisco CA United States of America

Genomic Sample Prep and Biomarker Assay Development DNA RNA Extraction NGS Assays Liquid Biopsy Antibody Validation More San Francisco United States of America

7th to 9th March 2016
San Francisco CA United States of America

Clinical NGS Diagnostics Translating Genomic Data to the Standard of Care San Francisco United States of America

7th to 9th March 2016
San Francisco CA United States of America

Genomics Sequencing Data Integration Analysis and Visualization San Francisco United States of America

10th to 11th March 2016
San Francisco CA United States of America

New Fronteirs in Gene Editing San Francisco United States of America

10th to 11th March 2016
London United Kingdom

HPLC Congress 2016 London United Kingdom

24th to 25th March 2016
Vienna Austria

2016 Genetics and Genomics Conference Vienna Austria

1st to 3rd June 2016
San Diego California United States of America

Genome Editing and Engineering Conference San Diego United States of America

18th to 19th February 2016
Breckenridge Colorado United States of America

Keystone Symposia Stem Cells and Cancer Breckenridge United States of America

6th to 10th March 2016
San Francisco CA United States of America

Clinical NGS Diagnostics Translating Genomic Data to the Standard of Care San Francisco United States of America

7th to 9th March 2016
Singapore

Human Genomics Singapore Singapore

8th to 10th November 2015
Kuala Lumpur Malaysia

The Probiotics Congress Asia Kuala Lumpur Malaysia

29th February to 1st March 2016

Whole Genome Sequencing Conference Speakers

Recommended Sessions

Related Journals

Are you interested in